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The Peptide Atlas

Tesamorelin

A stabilized version of growth-hormone-releasing hormone, engineered to resist breakdown so it lasts longer than the natural signal.

Class
Growth-hormone secretagogue (stabilized GHRH analog)
Evidence
Established
Status
FDA-approved (Egrifta).
Forms
Daily injection

What people use it for

The deep belly fat that resists diet, and the metabolic trouble that comes with it.

The signal

The same instruction sermorelin copies: the brain's request for the pituitary to release growth hormone. Tesamorelin is the version that made it through the full FDA process.

How it works

Like the other GHRH analogs, it prompts the pituitary to release your own growth hormone in natural pulses. Its best-documented downstream effect is on visceral fat, the deep abdominal fat around the organs.

What the research shows

The strongest trial record of any GHRH analog: in placebo-controlled Phase 3 trials it reduced visceral fat by roughly 15-18% over 6 to 12 months [1, 2], and later work found improvements in liver fat and fat quality [3]. The approval studies were in people with HIV-related fat accumulation, which is where the FDA label sits; research in other groups continues.

What people get wrong

That it's a weight-loss drug. The trials show it reduces visceral fat specifically, with little change in weight overall. Deep abdominal fat is the metabolically troublesome kind, so that's a real effect, but the scale mostly doesn't move.

References

  1. Falutz J et al., N Engl J Med (2007). Metabolic effects of a growth hormone-releasing factor in patients with HIV. PubMed
  2. Falutz J et al., J Clin Endocrinol Metab (2010). Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in HIV-infected patients with excess abdominal fat: pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials. PubMed
  3. Adrian S et al., AIDS (2021). Tesamorelin improves fat quality independent of changes in fat quantity. PubMed

Last reviewed 2026-08-24. Every reference is verified against the primary literature at review time. How the Atlas grades evidence