Ember™. The desire peptide.
Bring desire back. Feel like yourself. On your terms.
Ember™ is our PT-141 (bremelanotide) protocol, the only FDA-approved peptide for female desire. Non-hormonal. On-demand. You pick the form, a US-licensed physician prescribes online.
- FDA-approved active ingredient (bremelanotide) for HSDD in premenopausal women
- Works on the brain pathway, alone or alongside HRT
- Nasal spray or at-home injection, both as-needed, chosen at your online visit
From less than $5 a day
your first month
$161$12920% off
free shipping + free doctor review
Discount applied automatically at checkout, no code to enter.
2 minutes · No commitment until a provider approves
2019
Year FDA-approved
1,200+
Women in Phase 3 trials
45 min
To effect · lasts hours
LegitScript Certified
Licensed providers in your state
503A/B pharmacies, USP-grade
No charge until a provider approves
In the desire conversations we studied, nearly half of the women describing low desire never named a single treatment option. This page exists so you know yours: a licensed US physician, published prices, and medication from licensed US pharmacies.
From the Pepvio Listening Study, Edition 1 · August 2026PT-141 has been studied and written about for over two decades.
Written about in
In the research
What PT-141 actually is
Thirty-five seconds on the medication, and how getting it works.
- Cancel, pause, or switch protocols anytime, no annual commitment.
- Free doctor review and free shipping: you only pay for the medication, one monthly number with no surprise bills.
- Ongoing provider access: message your prescriber anytime through the patient portal.
Low desire that hasn't shifted with HRT alone
You've recognized HSDD (low desire that bothers you) and want help
Prefer a non-hormonal option to layer alongside or instead of HRT
FDA-approved active ingredient (bremelanotide) for HSDD in premenopausal women
Works on the brain pathway, alone or alongside HRT
Nasal spray or at-home injection, both as-needed, chosen at your online visit
You're not alone.
Postpartum. Perimenopause. SSRIs. Birth control. Stress. Life. Your libido drops for actual physiological reasons, not because something is wrong with you. PT-141 was approved for exactly this kind of low desire: the kind with a biological cause and a biological response.
You deserve to feel good.
Wanting to want again isn't selfish. It isn't frivolous. It's a real medical issue with a real medical answer.
How PT-141 works
PT-141 (bremelanotide) activates the melanocortin pathway in the brain — a system tied to arousal that's separate from estrogen and progesterone. It works on a brain receptor, not on hormones, which is why it can complement HRT rather than replace it.
Brain pathway, not hormones
Activates melanocortin-4 receptors in the central nervous system — the system involved in sexual arousal at the brain level.
Different from HRT
Doesn't change estrogen or progesterone levels. Works alongside HRT, or on its own.
FDA-approved for HSDD
Bremelanotide, the active ingredient, was FDA-approved in 2019 for hypoactive sexual desire disorder in premenopausal women.
Two ways to take it
A nasal spray or a small at-home injection — both used as needed, before intimacy.
What's actually behind it
PT-141 was approved by the FDA in 2019 after two large Phase 3 trials in premenopausal women with HSDD. The honest read: real, modest improvements in desire and distress vs placebo — and the only peptide the FDA has cleared for this indication.
FDA approval
2019
Bremelanotide approved for HSDD in premenopausal women
Pivotal trials
~2,400
Women across the two RECONNECT Phase 3 trials
FDA-approved peptides for female desire
1
Just this one — the others on the market work hormonally
Source: Kingsberg SA, et al. RECONNECT trial. Obstetrics & Gynecology, 2019; FDA approval letter for bremelanotide, 2019.
What the research says
Peer-reviewed work behind PT-141 / bremelanotide.
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
Kingsberg SA, et al.
Both RECONNECT trials showed statistically significant improvements in desire (FSFI-D) and reductions in distress (FSDS-DAO) vs placebo over 24 weeks.
DOI: 10.1097/AOG.0000000000003500Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial
Clayton AH, et al.
Earlier dose-finding work that established the 1.75mg subcutaneous dose later used in RECONNECT and approved by FDA.
DOI: 10.2217/whe-2016-0018Bremelanotide: an overview of preclinical CNS effects on female sexual function
Pfaus et al., 2007
Mechanism-of-action review: melanocortin receptor activation in central brain pathways involved in sexual arousal.
DOI: 10.1111/j.1743-6109.2007.00610.xTwo ways to take it. Pick what fits your life.
Nasal spray
A spray, used as needed before intimacy.
- Easy to travel with and keep on hand. Discreet
- Used as needed, before intimacy
15 mg per bottle
1 mg/ml · 15 ml
From $129 your first month
Best if you'd rather skip the needle.
At-home injection
A small injection about 45 minutes before, the form studied in the FDA's PT-141 trials.
- Steady, consistent dosing; longer, more forgiving window
- Small subcutaneous injection, like an insulin pen
10 mg per vial
2 mg/ml · 5 ml
From $199.20 your first month
Best if you want a longer timing window and steady, predictable dosing.
Take the pressure off. The medicine works better when you do.
The science is on your side, and PT-141 works best when you also consider how you set the scene.
- 01
Lower the stakes.
Desire often shows up after arousal, not before it. Willingness is enough to start. You don't have to feel 'in the mood' first.
- 02
Don't watch yourself.
Pressuring yourself to feel something on cue tends to block it. Presence beats performance every time.
- 03
Try it more than once.
The first time is information, not a verdict. Most women find their pattern over a few weeks of using it.
What women have been offered, and where PT-141 fits
| PT-141 | Testosterone | Nothing | |
|---|---|---|---|
| FDA-approved for women's libido | ✓ Yes, since 2019 | No, off-label for women | — |
| Non-hormonal | ✓ Yes | No, hormonal | — |
| On-demand (no daily commitment) | ✓ Yes | No, daily cream or weekly pellet | — |
| Time to effect | ✓ ~45 minutes | Weeks to months | — |
What happens after you click
- Step 1
Today
2-minute online visit. No charge unless a provider approves.
- Step 2
Within 24 hours
A US-licensed physician reviews your intake and approves a protocol that fits, or tells you it isn't right for you.
- Step 3
5–7 days
Your prescription arrives in discreet packaging from a licensed US pharmacy.
What's in this protocol
PT-141 (Bremelanotide)
Subcutaneous injection (1.75mg, ~45 min before) or nasal spray, both used as needed before intimacy; form picked at your online visit
The only FDA-approved peptide for female desire. PT-141 (bremelanotide) activates the central melanocortin pathway to trigger desire directly. Dosed on-demand, typically 45 minutes before intimacy. Non-controlled.
Flexible payment options available at checkout · Cancel anytime · HSA/FSA reimbursable (Letter of Medical Necessity available from your provider on request)
Inside your kit
- 1
Nasal spray bottle
If you choose the spray form. Used as needed.
- 2
Injection vial + sterile syringes
If you choose the injectable form. On-demand use.
- 3
Alcohol swabs + sharps container
Included with the injectable kit.
- 4
Dosing card + provider messaging
Personalized schedule. Message your provider anytime.
Reviewed and prescribed by a US-licensed physician
Every Pepvio prescription is reviewed by a US-licensed physician. We're not a supplement company. We don't sell anything that doesn't require a prescription. Your physician decides if PT-141 is right for you based on your intake, and if it isn't, you aren't charged.
Wanting to feel good is reason enough.
Start your visit. A US-licensed physician reviews your intake, usually within 24 hours, and prescribes the form that fits you. You're not charged until they approve a protocol.
See if I qualifyPepvio protocols require a valid prescription from a licensed healthcare provider. All medications are compounded by licensed pharmacies. Pepvio does not provide medical advice; all medical decisions are made by licensed providers in our network. Individual results may vary.