Bring desire back. Feel like yourself. On your terms.
PT-141 (bremelanotide) — the only FDA-approved peptide for female desire. Non-hormonal. On-demand. Prescribed online by a US-licensed physician.
- FDA-approved active ingredient (bremelanotide) for HSDD in premenopausal women
- Brain pathway — works on its own or alongside HRT
- Daily spray or on-demand injection — picked at your online visit
From less than $7 a day
$199 billed monthly·all-inclusive: provider, medication, shipping
2 minutes · No commitment until a provider approves
2019
Year FDA-approved
1,200+
Women in Phase 3 trials
45 min
To effect · lasts hours
Licensed providers in your state
503A/B pharmacies, USP-grade compounding
No charge until a provider approves
- Cancel, pause, or switch protocols anytime — no annual commitment.
- All-inclusive pricing — provider, medication, and shipping in one monthly number. No surprise bills.
- Ongoing provider access — message your prescriber anytime through the patient portal.
Low desire that hasn't shifted with HRT alone
You've recognized HSDD (low desire that bothers you) and want help
Prefer a non-hormonal option to layer alongside or instead of HRT
FDA-approved active ingredient (bremelanotide) for HSDD in premenopausal women
Brain pathway — works on its own or alongside HRT
Daily spray or on-demand injection — picked at your online visit
You're not alone.
Postpartum. Perimenopause. SSRIs. Birth control. Stress. Life. Your libido drops for actual physiological reasons — not because something is wrong with you. PT-141 was approved for exactly this kind of low desire: the kind with a biological cause and a biological response.
You deserve to feel good.
Wanting to want again isn't selfish. It isn't frivolous. It's a real medical issue with a real medical answer.
How PT-141 works
PT-141 (bremelanotide) activates the melanocortin pathway in the brain — a system tied to arousal that's separate from estrogen and progesterone. It works on a brain receptor, not on hormones, which is why it can complement HRT rather than replace it.
Brain pathway, not hormones
Activates melanocortin-4 receptors in the central nervous system — the system involved in sexual arousal at the brain level.
Different from HRT
Doesn't change estrogen or progesterone levels. Works alongside HRT, or on its own.
FDA-approved for HSDD
Bremelanotide, the active ingredient, was FDA-approved in 2019 for hypoactive sexual desire disorder in premenopausal women.
Two ways to take it
A daily nasal spray, or a small at-home injection you take when you want it to work.
What's actually behind it
PT-141 was approved by the FDA in 2019 after two large Phase 3 trials in premenopausal women with HSDD. The honest read: real, modest improvements in desire and distress vs placebo — and the only peptide the FDA has cleared for this indication.
FDA approval
2019
Bremelanotide approved for HSDD in premenopausal women
Pivotal trials
~2,400
Women across the two RECONNECT Phase 3 trials
FDA-approved peptides for female desire
1
Just this one — the others on the market work hormonally
Source: Kingsberg SA, et al. RECONNECT trial. Obstetrics & Gynecology, 2019; FDA approval letter for bremelanotide, 2019.
What the research says
Peer-reviewed work behind PT-141 / bremelanotide.
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
Kingsberg SA, et al.
Both RECONNECT trials showed statistically significant improvements in desire (FSFI-D) and reductions in distress (FSDS-DAO) vs placebo over 24 weeks.
Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial
Clayton AH, et al.
Earlier dose-finding work that established the 1.75mg subcutaneous dose later used in RECONNECT and approved by FDA.
The melanocortin system and sexual function: a review
Pfaus JG, et al.
Mechanism-of-action review covering MC4R activation in the central nervous system and its role in arousal across animal models and human studies.
Two ways to take it. Pick what fits your life.
Daily nasal spray
Take it every day, the same way you'd take a vitamin.
- Discreet — no needles
- Most women need 2–4 weeks of daily use to dial in their optimal response — timing, dose, personal pattern
- Builds desire as a baseline part of your routine
Best if you want it always available. No advance planning.
On-demand injection
Take it 45 minutes before intimacy, when you want the effect.
- Works the session you take it
- Onset in ~45 minutes; effect lasts several hours
- Small subcutaneous injection (similar to insulin pen)
Best if you prefer precision timing. Deliberate use, no daily commitment.
Take the pressure off. The medicine works better when you do.
PT-141 is a tool, not a switch. The science is on your side — but so is the way you set the scene.
- 01
Lower the stakes.
Desire often shows up after arousal, not before it. Willingness is enough to start. You don't have to feel 'in the mood' first.
- 02
Don't watch yourself.
Pressuring yourself to feel something on cue tends to block it. Presence beats performance every time.
- 03
Try it more than once.
The first time is information, not a verdict. Most women find their pattern over a few weeks of using it.
What women have been offered — and where PT-141 fits
| PT-141 | Testosterone | Nothing | |
|---|---|---|---|
| FDA-approved for women's libido | ✓ Yes, since 2019 | No — off-label for women | — |
| Non-hormonal | ✓ Yes | No — hormonal | — |
| On-demand (no daily commitment) | ✓ Yes | No — daily cream or weekly pellet | — |
| Time to effect | ✓ ~45 minutes | Weeks to months | — |
What happens after you click
- Step 1
Today
2-minute online visit. No charge unless a provider approves.
- Step 2
Within 24 hours
A US-licensed physician reviews your intake and approves a protocol that fits — or tells you it isn't right for you.
- Step 3
5–7 days
Your prescription arrives in discreet packaging from a licensed US pharmacy.
What's in this protocol
PT-141 (Bremelanotide)
Subcutaneous injection (1.75mg, ~45 min before intimacy) or daily nasal spray — form picked at your online visit
The only FDA-approved peptide for female desire. PT-141 (bremelanotide) activates the central melanocortin pathway to trigger desire directly — dosed on-demand, typically 45 minutes before intimacy. Non-controlled.
Flexible payment options available at checkout · Cancel anytime · HSA/FSA reimbursable (Letter of Medical Necessity available from your provider on request)
Inside your kit
- 1
Nasal spray bottle
If you choose the spray form. Daily use.
- 2
Injection vial + sterile syringes
If you choose the injectable form. On-demand use.
- 3
Alcohol swabs + sharps container
Included with the injectable kit.
- 4
Dosing card + provider messaging
Personalized schedule. Message your provider anytime.
Reviewed and prescribed by a US-licensed physician
Every Pepvio prescription is reviewed by a US-licensed physician. We're not a supplement company. We don't sell anything that doesn't require a prescription. Your physician decides if PT-141 is right for you based on your intake — and if it isn't, you aren't charged.
Wanting to feel good is reason enough.
Start your visit. A US-licensed physician reviews your intake — usually within 24 hours — and prescribes the form that fits you. You're not charged until they approve a protocol.
See if I qualifyPepvio protocols require a valid prescription from a licensed healthcare provider. All medications are compounded by licensed pharmacies. Pepvio does not provide medical advice; all medical decisions are made by licensed providers in our network. Individual results may vary.