More energy in 30 days. No IV, no clinic.
Sharper mind + faster recovery.
NAD+ is your body's natural energy supply, which fades with age. Restore it directly with a nasal spray or a small at-home injection, prescribed by U.S. physicians.
- Real prescription NAD+, not a supplement
- Free doctor review and free shipping, you only pay for the medication
- Compounded for each prescription by a US licensed pharmacy
From less than $6 a day
your first month
$199$15920% off
free shipping + free doctor review
Discount applied automatically at checkout, no code to enter.
2 minutes · No commitment until a provider approves
~50%
Less NAD+ by midlife
Every cell
runs on NAD+
24 hours
Physician review
LegitScript Certified
Licensed providers in your state
503A/B pharmacies, USP-grade
No charge until a provider approves
- Cancel, pause, or switch protocols anytime, no annual commitment.
- Free doctor review and free shipping: you only pay for the medication, one monthly number with no surprise bills.
- Ongoing provider access: message your prescriber anytime through the patient portal.
Energy not what it used to be, and the usual fixes haven't moved it
Already tried NMN/NR oral supplements and want something more direct
Researching the IV-clinic protocol as a subscription alternative
Real prescription NAD+, not a supplement
Free doctor review and free shipping, you only pay for the medication
Compounded for each prescription by a US licensed pharmacy
It's not just aging.
You know the feeling. The 2pm wall you push through with another coffee. Waking up tired after a full night's sleep. Taking longer to bounce back from a workout, or a long week, than you used to. It's easy to chalk it up to getting older, or to figure you're just not trying hard enough. But there's a real, physical reason. Your body runs on NAD+, and by 50 you have about half of what you had at 20, so you feel it as flagging energy, foggy focus, and slower recovery, even when your sleep and diet haven't changed. Prescription NAD+ puts back what you've lost, directly, without your gut breaking it down first.
What NAD+ actually does in your cells
Four jobs NAD+ has to keep up with — and why levels matter as you age.
Cellular energy
Your cells need NAD+ to turn food into ATP, the fuel they actually run on. No NAD+, no energy.
DNA repair
The enzymes that patch up day-to-day DNA damage burn through NAD+ doing it. Less NAD+, slower repair.
Sirtuins
Sirtuins are a family of cellular-housekeeping enzymes studied heavily in longevity research. They run on NAD+.
Falls sharply with age
By 50, levels are roughly half of what they were at 20 — and the slide continues. Topping them back up is the whole idea.
NAD+ levels decline sharply with age
Skin-cell NAD+ measured by mass spectrometry across age groups.
Source: Massudi et al. Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. PLOS ONE, 2012.
What the research says
Three peer-reviewed studies on NAD+ in human and mammalian longevity.
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
Massudi et al., 2012
Cellular NAD+ levels in human skin fall by ~50% between age 20 and age 50, with continued decline thereafter.
DOI: 10.1371/journal.pone.0042357NAD+ intermediates: the biology and therapeutic potential of NMN and NR
Yoshino et al., 2018
NAD+ precursors NMN and NR demonstrate efficacy in restoring cellular NAD+ levels and improving metabolic markers in mammalian models.
DOI: 10.1016/j.cmet.2017.11.002Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens et al., 2018
Daily NAD+ precursor supplementation in adults aged 55–79 sustainably elevated whole-blood NAD+ levels with no significant adverse events.
DOI: 10.1038/s41467-018-03421-7Two ways to take it. Pick what fits your life.
Nasal spray
A spray you take at home. Pick your strength at checkout.
- No needles
- Easy to travel with and keep on hand
- Two strengths at the same price, so you can adjust with your physician later
Choose your strength
100 mg/ml
1.5 g or 3 g per bottle
15 ml or 30 ml
300 mg/ml
4.5 g or 9 g per bottle
15 ml or 30 ml
From $159.20 your first month, either strength
Best if you'd rather skip the needle.
At-home injection
A small subcutaneous injection you take a few times a week.
- A precise dose, fully absorbed every time
- The same molecule longevity clinics run as an IV drip
- Small subcutaneous injection, like an insulin pen
a full gram (1,000 mg) per vial
100 mg/ml · 10 ml
From $239.20 your first month
Best if you want predictable dosing and absorption.
What people have been trying, and where prescription NAD+ fits
| Pepvio NAD+ | IV drip clinic | Oral NMN/NR | |
|---|---|---|---|
| Reaches your bloodstream | ✓ Yes, direct to bloodstream | ✓ Yes | No, broken down in the gut |
| Done at home | ✓ Yes, self-administered | No, in-clinic (hours per visit) | ✓ Yes |
| Gentle, low dose | ✓ Small dose, spray or injection | No, fast IV flush | ✓ Yes |
| Cost | ✓ One monthly subscription | ~$300–600 per session | $, but low absorption |
| Prescribed by a US physician | ✓ Yes, US pharmacy | ✓ Yes, at the clinic | No, over-the-counter |
From Pepvio patients
Honestly, we were a bit skeptical at first, but within a couple of weeks of starting NAD+, the daily brain fog just lifted. My energy levels during the workday feel much more consistent now, I'm staying engaged through the day without crashing by mid-afternoon. It's given me a noticeable second wind that makes sticking to my evening routine and family time so much easier.
For me, it's been about mental clarity and just feeling more like myself again. I notice a clear difference in my focus and stamina throughout the day. It's become a smooth, reliable boost to our daily routine.
Individual results may vary.
What happens after you click
- Step 1
Today
2-minute online visit. No charge unless a physician approves.
- Step 2
Within 24 hours
A US-licensed physician reviews your intake and approves a protocol that fits, or tells you it isn't right for you.
- Step 3
5–7 days
Your prescription arrives in discreet packaging from a licensed US pharmacy.
What's in this protocol
NAD+
Subcutaneous injection several times a week, or a nasal spray. Low starting dose, titrated by your provider.
Your body's natural energy supply at the cellular level. Levels drop roughly in half between age 20 and 50, and keep fading. Topping it back up is the foundational longevity intervention clinicians have been doing for years, now in a small self-administered home injection you take a few times a week, instead of an IV-clinic visit.
Flexible payment options available at checkout · Cancel anytime · HSA/FSA reimbursable (Letter of Medical Necessity available from your provider on request)
Inside your kit
- 1
NAD+ injection vial
Compounded by a licensed pharmacy in your state.
- 2
Sterile syringes
Sized for subcutaneous self-administration.
- 3
Alcohol swabs
Single-use, individually sealed.
- 4
Sharps disposal container
FDA-cleared, included with first shipment.
- 5
Dosing instructions
Provider-personalized dosing schedule.
Reviewed and prescribed by a US-licensed physician
Every Pepvio prescription is reviewed by a US-licensed physician. Real intake review, real prescription decision, real follow-up adjustments. We're not a supplement company. Your physician decides if NAD+ is right for you based on your intake, and if it isn't, you aren't charged.
Ready to start?
Take a free 2-minute assessment. If a licensed provider approves your protocol, your medication ships directly to your door. Not approved? Your card is never charged.
See if I qualifyPepvio protocols require a valid prescription from a licensed healthcare provider. All medications are compounded by licensed pharmacies. Pepvio does not provide medical advice; all medical decisions are made by licensed providers in our network. Individual results may vary.